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Your search term(s) "diabetic neuropathy" returned 76 results.
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Controversies in Treating Diabetes: Clinical and Research Aspects. Totowa, NJ: Humana Press. 2008. 367 p.
This book addresses diabetes controversies, specifically in the etiology and management of the disease. The volume covers commonly accepted forms of therapies and complications, as well as new and emerging advances, therapies, and inadequacies in several standard treatments. The book offers 17 chapters, each written by experts in the field. Topics are patient selection for pancreas transplantation; the effectiveness of islet transplantation; appropriate treatment for metabolic syndrome; reducing the complications of diabetes through intensive treatment; when to introduce insulin into the treatment for type 2 diabetes; the prevention of diabetic retinopathy; the evaluation, management, and controversies in treatments for diabetic neuropathies; endpoints in clinical research studies on diabetic neuropathy; intensive insulin therapy for the critically ill patient; the recent explosion in childhood type 1 and type 2 diabetes; weight loss in type 2 diabetes patients; a unifying hypothesis of diabetic complications; the diabetic foot; developments in incretins; controversies in the evaluation and management of lipid disorders in diabetes; polypharmacy for the treatment of type 2 diabetes; and the natural history and clinical aspects of comorbid depression and diabetes. Each chapter includes an outline, a summary, and a list of references. A list of contributors and their affiliations is provided. A subject index concludes the volume.
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Diabetes Skin And Foot Care: In Step. 4th ed. Timonium, MD: Milner-Fenwick. 2008. (DVD).
This DVD program reviews the importance of skin and foot care for people who have diabetes. The program describes practical suggestions for maintaining healthy skin and feet, how to check for problems, appropriate footwear, and how to work in tandem with a health care provider to minimize any complications. The program depicts the use of the monofilament test that is used to detect diabetic neuropathy or nerve disease, particularly in the extremities. Viewers are reminded of the importance of a self-management plan for keeping diabetes under control and preventing or minimizing these complications with good blood glucose control. The video depicts a variety of people who share their experiences with diabetes management and self-care. Simple graphics are used to explain most of the topics covered. Viewers are referred to the American Association of Diabetes Educators website for more information and to find a local diabetes educator.
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Diabetic Neuropathies: Endpoints in Clinical Research Studies. IN: LeRoith, D.; Vinik, A., eds. Controversies in Treating Diabetes: Clinical and Research Aspects. Totowa, NJ: Humana Press. 2008. pp 135-156.
This chapter about clinical trials for the treatment of diabetic neuropathy (DN) is from a book that addresses diabetes controversies, specifically in the etiology and management of the disease. The authors of this chapter note that clinical trials of agents for the treatment of DN have been troubled by a lack of agreement on appropriate endpoints, as well as a lack of translation from success in animal studies to success in human clinical trials. Much of the controversy surrounds indexes that are used to reliably measure changes in nerve function, which translate into changes in quality of life, activities of daily living, and health of the individual. In addition, there has been a failure to recognize that the relief of the patient’s symptoms does not necessarily equate to change in the underlying biological disorder. The authors focus on the various measures that have been used for the evaluation of symptoms and those that quantify nerve function, and then compare and contrast the reasons for failure of different measures of neurological deficits; the prevention of degeneration of specific small fiber, large fiber, and autonomic nerve deficits; and those treatments that have potential for reversal of these deficits. A final section considers the identification of candidates for participation in research studies. 88 references.
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Preventing Long Term Complications of Diabetes. 4th ed. Timonium, MD: Milner-Fenwick. 2008. (DVD).
This DVD program explains the long-term complications of diabetes, including atherosclerosis and other cardiovascular diseases, kidney disease, eye disease, and neuropathy. Viewers are reminded of the importance of a self-management plan for keeping diabetes under control and preventing or minimizing these complications. The management plan outlined includes patient education, healthy eating, physical activity and exercise, medications, self-monitoring of blood glucose (SMBG), and the glycosylated hemoglobin (A1C) test used for longer term monitoring of blood glucose levels. The video depicts a variety of people who share their experiences with complications and diabetes management. Simple graphics are used to explain most of the topics covered. Viewers are referred to the American Association of Diabetes Educators website for more information and to find a local diabetes educator.
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Treatment of Diabetic Neuropathy and Neuropathic Pain: How Far Have We Come?. Diabetes Care. 31(Suppl 2): S255-S261. February 2008.
This article explores the current and proposed treatment of diabetic neuropathy and neuropathic pain, common complications in people with diabetes. Treatment is based on four components: causal treatment aimed at achieving normal blood glucose levels; treatment based on pathogenetic mechanisms; symptomatic treatment; and avoidance of risk factors and complications. Because the pathogenesis of diabetic neuropathy is multifactorial, treatments must use different approaches. The authors review some of the new treatments being evaluated in clinical trials, including alpha-lipoic acid and epalrestat, which are already available in some countries. Some new analgesic drugs have been recently approved in the United States, including duloxetine and pregabalin, but the pharmacologic treatment of chronic painful diabetic neuropathy remains a challenge for the physician and patient. Risk factors that can contribute to painful diabetic neuropathy including alcohol consumption, as well as traditional cardiovascular risk factors such as hypertension, smoking, and cholesterol; these factors need to be prevented or treated to help patients coping with diabetic neuropathy. 3 tables. 43 references.
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Diabetic Neuropathies: Evaluation, Management and Controversies in Treatment Options. IN: LeRoith, D.; Vinik, A., eds. Controversies in Treating Diabetes: Clinical and Research Aspects. Totowa, NJ: Humana Press. 2008. pp 109-134.
This chapter about diabetic neuropathies (DN) is from a book that addresses diabetes controversies, specifically in the etiology and management of the disease. The author of this chapter focuses on the evaluation, management, and controversies in treatment options for DN, a heterogeneous group of disorders that include a wide range of abnormalities. Distal symmetric polyneuropathy, the most common form of DN, usually involves small and large nerve fibers. Small nerve fiber neuropathy often presents with pain without objective signs or electrophysiologic evidence of nerve damage. The greatest risk of small fiber neuropathy is foot ulceration and subsequent gangrene and amputation. Large nerve fiber neuropathies produce numbness, ataxia, and incoordination, which can impair activities of daily living and contribute to falls and fractures. Symptomatic therapy is available for DN, but preventive strategies and patient education are still the key factors in reducing complication rates and mortality. The author reports on some research studies on new agents that target the pathophysiological mechanisms of DN. New drugs have recently been approved in the United States for the treatment of neuropathic pain of diabetes, including duloxetine. The chapter concludes with a description of adjunctive management strategies such as foot protection and ulcer prevention; mechanical measures, including transcutaneous nerve stimulation; and surgery for the treatment of neuropathy, notably for nerve tunnel entrapment syndromes. 3 figures. 2 tables. 96 references.
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Diabetic Neuropathies: the Nerve Damage of Diabetes. Bethesda, MD: National Diabetes Information Clearinghouse. 2008. 11 p.
Diabetic neuropathies are nerve disorders caused by many of the abnormalities common to diabetes, such as high blood glucose. Neuropathy can affect nerves throughout the body, causing numbness and sometimes pain in the hands, arms, feet, or legs, and problems with the digestive tract, heart, sex organs, and other body systems. This fact sheet defines diabetic neuropathy and discusses its causes, symptoms, the different types of diabetic neuropathy, peripheral neuropathy, autonomic neuropathy and its complications, hypoglycemia unawareness, the impact of neuropathy on the cardiovascular and digestive systems, proximal neuropathy, focal neuropathy, diagnostic tests used to confirm the presence of diabetic neuropathy, and treatment strategies, including pain relief. Treatment for diabetic neuropathies first involves bringing blood glucose levels within the normal range. Good blood glucose control may help prevent or delay the onset of further problems. The fact sheet stresses that foot care is an important part of treatment. People with neuropathy need to inspect their feet daily for any injuries. Untreated injuries increase the risk of infected foot sores and amputation. Treatment includes pain relief and other medications as needed, depending on the type of nerve damage. Smoking significantly increases the risk of foot problems and amputation. Readers are encouraged to work closely with their health care providers for helping in quitting smoking. The fact sheet concludes with a list of publications available from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Contact information for 12 organizations is provided. The back cover of the fact sheet describes the goals and activities of the National Diabetes Information Clearinghouse (NDIC), a Government service that provides information about diabetes to people with diabetes and to their families, health care professionals, and the public. 2 figures. 1 table.
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How to Keep Your Feet: Avoiding Peripheral Vascular Disease. Diabetes Forecast. 61(2): 50-51. February 2008.
This article reminds readers of the importance of careful foot care in people with diabetes. The author describes peripheral vascular disease (PVD), the cardiovascular complication of diabetes that contributes to foot problems, and diabetic neuropathy, nerve damaged caused by high blood glucose levels. The first warning sign of danger to the feet is usually an ulcer, which can lead to one of the most feared complications of diabetes: amputation of a foot or leg. The author reviews some of the steps to a thorough physical examination that should be performed by the health care provider each time a patient with diabetes comes in for a check-up. The article describes the Ankle-Brachial Index (ABI), a simple test measuring the balance between the blood pressure in the arms and the feet, which can be an important indication of problems associated with vascular disease. One sidebar emphasizes the importance of quitting smoking immediately because the greatest risk of PVD and foot amputation is in people with diabetes who smoke cigarettes. 2 figures.
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Microvascular And Macrovascular Complications of Diabetes. Clinical Diabetes. 26(2): 77-82. Spring 2008.
This article is part of a 12-part series for physicians in training that reviews the fundamentals of diabetes care; this article summarizes the microvascular and macrovascular complications of the disease. The author emphasizes the importance of protecting the body from hyperglycemia, the complications of which are the major source of morbidity and mortality from both type 1 and type 2 diabetes. The article discusses the microvascular complications, including diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy. The article outlines the macrovascular complications of diabetes, notably the increased risk of cardiovascular diseases. Readers are reminded of the importance of monitoring their patients for these complications, implementing therapies that counter hyperglycemia, using drug therapies and lifestyle changes to manage hypertension, and regularly measuring blood pressure and blood glucose levels. Recommendations for various monitoring and screening tests are also provided. 39 references.
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Prevent Diabetes Problems: Keep Your Nervous System Healthy. Bethesda, MD: National Diabetes Information Clearinghouse. 2008. 27 p.
Diabetes is a disease in which blood glucose levels are above normal. People who have diabetes often experience complications due to these high blood glucose levels, including in the heart, blood vessels, eyes, and kidneys. This booklet, written in nontechnical language, answers common questions about nerve problems that can be caused by diabetes. Topics covered include daily activities that can help a person with diabetes stay healthy; foot care; the physiology of the nervous system; how diabetes can affect the peripheral, autonomic, and cranial nerves; the symptoms of nerve damage; and where to get additional information about diabetes nerve problems, including the contact information for resource organizations. The booklet concludes with a section that briefly summarizes the activities of the National Diabetes Information Clearinghouse (NDIC). The booklet is illustrated with black-and-white line drawings and includes a brief pronunciation guide for some of the medical terms used. 14 figures.
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