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Your search term(s) "IGA nephropathy" returned 8 results.

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IGA Nephropathy. Bethesda, MD: National Kidney and Urologic Diseases Information Clearinghouse. 2008. 4 p.

This fact sheet describes IgA nephropathy, a kidney disorder that occurs when IgA, a protein that helps fight infections, settles in the kidneys. After many years, IgA deposits may cause the kidneys to leak blood and sometimes protein into the urine. About 25 percent of adults with IgA nephropathy eventually development total kidney failure. Written in a question-and-answer format, the fact sheet reviews the symptoms of IgA nephropathy, risk factors, the causes of IgA nephropathy, diagnostic tests used to confirm the condition, and treatment options, including treatment for the concomitant high blood pressure and high cholesterol levels. A final section briefly reviews current research programs in this area. The fact sheet includes the contact details for five resource organizations through which readers can get more information and a description of the goals and activities of the National Kidney and Urologic Diseases Information Clearinghouse.

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Management of Dialysis Patients with Celiac Disease. Practical Gastroenterology. 31(6): 70-72, 77-80, 82. July 2007.

This article considers the management of dialysis patients who also have celiac disease, a condition of gluten intolerance. The author notes that these two diseases are not often reported in the same patient, but celiac disease is sometimes listed as one of the associated diseases of IgA nephropathy. There are no written guidelines for managing these combined diseases, because of the rarity of their co-occurrence, or perhaps because they are underdiagnosed. Celiac disease is characterized by inflammation of the small intestine and malabsorption after the ingestion of gluten; thus, celiac disease is managed by life-long avoidance of gluten in the diet. Kidney disease is manifested by fluid and electrolyte imbalance, which also involves life-long dietary restrictions. This article reviews the renal dietary guidelines and provides suggestions on how to combine those guidelines with the required changes to manage celiac disease. Specific topics include malnutrition, potassium, fluid and sodium, renal bone osteodystrophy, phosphorus, common medications of dialysis patients, and socioeconomic considerations. One table provides a renal and gluten-free diet in a chart format. 4 tables. 9 references.

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Chronic Nephritis in Children: With Emphasis on IGA Nephropathy. IN: Hogg, R., ed. Kidney Disorders in Children and Adolescents: A Global Perspective of Clinical Practice. New York, NY: Informa Healthcare USA. 2006. pp 103-116.

This chapter about chronic nephritis is from a textbook that presents a global perspective of clinical practice regarding kidney disorders in children and adolescents. The authors define chronic nephritis as a slow but persistent form of renal disease that is often accompanied by proteinuria, hematuria, and/or hypertension. The most common form of chronic nephritis that results in end-stage renal disease (ESRD) in both children and adult patients around the world is IgA nephropathy, which is the primary focus of this chapter. The authors discuss epidemiology, pathology, etiology, pathogenesis, predisposing genetic factors, the mechanism of progression of disease in the kidneys, light microscopy findings, clinical features, laboratory studies for chronic nephritis, differential diagnosis, and treatment of IgA nephropathy. The authors conclude that there are multiple factors to consider when deciding whether to treat a child with IgA nephropathy or some other form of chronic nephritis; thus, primary care physicians should seek pediatric nephrology consultation. Because of this complexity, specific treatment options are not discussed in this text. The chapter includes black-and-white illustrations and photographs and concludes with an extensive list of references. 9 figures. 2 tables. 61 references.

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Glomerular Diseases. Bethesda, MD: National Kidney and Urologic Diseases Information Clearinghouse. 2006. 12 p.

This fact sheet reviews glomerular diseases, which involve problems with the glomeruli, the tiny units within the kidney where blood is cleaned. The fact sheet focuses on glomerulonephritis, defined as inflammation of the membrane tissue in the kidney; and glomerulosclerosis, the scarring or hardening of the tiny blood vessels within the kidney. Written in a question-and-answer format, the fact sheet covers the anatomy and function of the kidneys, how glomerular diseases interfere with kidney function, the symptoms of glomerular disease, diagnostic tests used to confirm glomerular disease, the causes of glomerular disease, renal failure, and end-stage renal disease (ESRD). Specific diseases covered include systemic lupus erythematosus (SLE), Goodpasture's syndrome, IgA nephropathy, Alport syndrome, infection-related glomerular disease, bacterial endocarditis, diabetic nephropathy, focal segmental glomerulosclerosis, and minimal change disease (MCD). The booklet summarizes the points covered, provides a brief glossary of terms, lists resource organizations for readers seeking additional information, and a briefly describes the goals and activities of the National Kidney and Urologic Diseases Information Clearinghouse. 2 figures.

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Kidney Disorders in Children and Adolescents: A Global Perspective of Clinical Practice. New York, NY: Informa Healthcare USA. 2006. 266 p.

This textbook presents a global perspective of clinical practice regarding kidney disorders in children and adolescents. The book emphasizes diagnosis and treatment, rather than etiology, pathology, and pathogenesis, which are covered in other textbooks. The text includes 22 chapters: normal kidney function and development and the choice of laboratory studies in children; radiographic studies in children with kidney disorders; congenital abnormalities of the kidney and urinary tract; neonatal kidney problems; mass screening for kidney disease in children; hematuria and proteinuria; the nephrotic syndrome; acute nephritis; chronic nephritis in children, particularly IgA nephropathy; the evaluation, monitoring, and therapy of hypertension; cardiovascular disease in patients with kidney disorders in childhood and adolescence; urinary tract infections and vesicoureteral reflux in children; nocturnal enuresis and voiding disorders; renal tubular disorders; acute renal failure and hemolytic uremic syndrome; chronic renal failure and dialysis options; the effects of kidney disorders on the endocrine system; nutritional and growth aspects of the care of children with kidney disease; immunization and anti-microbial therapy for children with chronic kidney disease (CKD); the social and developmental consequences of chronic kidney disease in children; renal transplantation in childhood; and the transition of children with renal diseases into adulthood. Each chapter includes black-and-white illustrations and photographs and concludes with an extensive list of references. The textbook begins with a section of full-color plates and concludes with a detailed subject index.

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Oculorenal Manifestations in Systematic Autoimmune Diseases. American Journal of Kidney Diseases. 43(2): 209-222. February 2004.

Vasculitides form a heterogeneous group of diseases characterized by blood-vessel inflammation and necrosis (tissue death). Systemic necrotizing vasculitis is characterized by inflammation of blood vessels, which often affects the eyes and kidneys. Vasculitides have a wide spectrum of manifestations because of the involvement of arteries and other vessels of various sizes and locations. Early diagnosis and prompt treatment may decrease the morbidity and mortality associated with systemic autoimmune diseases. In addition, the eyes and kidneys can provide clues to the diagnosis of many systemic diseases and many important complications of these diseases occur in the eye. Therefore, examination of the eyes and kidneys should be a routine and important part of a general examination in systemic diseases. This article reviews the major types of oculorenal manifestations in systemic autoimmune diseases. Diseases discussed include giant cell (temporal) arteritis, polyarteritis nodosa, Kawasaki disease, Wegener's granulomatosis and microscopic polyarteritis, Goodpasture's syndrome, IgA nephropathy and Henoch-Schonlein purpura nephritis, Churg-Strauss syndrome, Behcet's disease, systemic lupus erythematosus, primary antiphospholipid syndrome (APS), sarcoidosis, Sjogren's syndrome, cryoglobulinemia, and tubulointerstitial nephritis and uveitis syndrome. 6 figures. 124 references.

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Renal Risks of an Emerging 'Epidemic' of Obesity: The Role of Adipocyte-Derived Factors. Dialysis and Transplantation. 33(1): 11-21. January 2004.

Obesity has reached epidemic proportions in the affluent societies of the world, especially during the last two decades. Recently, there has been growing awareness and concern regarding rapidly emerging renal (kidney) complications of obesity. Obesity appears to play a central contributory role in the genesis of systemic hypertension (high blood pressure), nephrotic-range proteinuria (protein in the urine) with focal segmental glomerulosclerosis (FSGS) and renal cell carcinoma (kidney cancer), apart from the likely impact that the obesity has on the outcomes of patients on long-term dialysis and those with renal transplants. This article explores the renal risks of this emerging epidemic of obesity, focusing on the role of adipocyte-derived factors. Obesity-related FSGS has characteristic clinicopathological features, i.e., minimal clinical edema and more or less normal levels of serum albumin, cholesterol, and blood pressure. FSGS may progress to end stage renal disease (ESRD) in about 50 percent of cases. In addition, severe obesity may enhance the progression to ESRD of preexisting nephropathies such as IgA nephropathy. Strategies such as weight reduction early in the course of the disease, in conjunction with the judicious use of ACE inhibitors and possibly statins, might improve the outcome of obesity-related hypertension and nephropathy. 2 figures. 1 table. 90 references.

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Tacrolimus Therapy in Pediatric Patients with Treatment-Resistant Nephrotic Syndrome. Pediatric Nephrology. 19(3): 281-287. March 2004.

This article reports on a retrospective analysis of 16 children started on tacrolimus with various types of treatment-resistant nephrotic syndrome. In the group, there are 13 patients with focal glomerulosclerosis, 1 minimal change disease, and 2 IgA nephropathy with nephrosis. The mean age of the children was 11.4 years (range 3.5 to 18.1 years) with a mean age at diagnosis of 5.6 years (range 1.6 to 13.3 years). All patients initially received prednisone 2 milligrams per kilogram per day. Other therapies for 15 of 16 included cyclosporine (n = 15), chlorambucil (n = 5), mycophenolate mofetil (n = 5), levamisole (n = 3), i.v. methylprednisolone (n = 3), and cyclophosphamide (n = 2). The major indication for the initiation of tacrolimus included treatment resistance or dependence (n = 15) and intolerable side effects from other therapies (n = 1). The average time from the diagnosis to initiation of tacrolimus was 5.3 years. Thirteen patients (81 percent) went into a complete remission within an average of 2 months, with 3 patients relapsing while on treatment. Three patients did not respond. Of these, 2 had partial remissions (13 percent) and 1 failed to respond. Adverse events included anemia (n = 1), seizure (n = 1), worsening or new-onset hypertension (n = 5), and sepsis (n = 1). All patients remained on tacrolimus. The authors conclude that tacrolimus is an effective, well-tolerated medication for treatment-resistant forms of nephrotic syndrome in children, with a complete remission rate of 81 percent and a partial remission rate of 13 percent. 1 figure. 3 tables. 37 references.

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